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Women with high DHEAS levels have better Cognitive Function

July 12, 2009  |  Posted in  Steroids Blog

Women with high DHEAS levels have better Cognitive FunctionAccording to a new study published in the Journal of Clinical Endocrinology & Metabolism (JCEM), women with higher levels of hormone precursor DHEAS were found to have better cognitive function than their counterparts with lower levels.

It was revealed during the study that women with higher circulating levels of Dehydroepiandrosterone (DHEA) in the form of DHEAS (DHEA sulfate) fared better when it comes to executive function, concentration, and working memory tests as per Dr. Susan Davis of the Monash University in Victoria, Australia, and lead author of the study.

From News-Medical.Net:

“This study provides the first evidence that DHEAS is favorably associated with cognitive function,” said Dr. Susan Davis of the Monash University in Victoria, Australia, and lead author of the study. “My colleagues and I found that circulating DHEAS was significantly positively associated with a higher score for a test of executive function, and in the areas of simple concentration and working memory higher DHEAS levels were positively associated with higher scores for women with at least 12 years of education.”

DHEA is a steroid precursor, which means that it is converted in the body to steroid hormones such as testosterone and estrogen. It is the most abundant circulating sex steroid in women.

Previous studies suggest that DHEA and DHEAS may have neuroprotective effects. These studies also suggest that the decline in the production of these steroids with healthy aging may contribute to neuronal dysfunction and degeneration, and thus cognitive decline.

Maintenance of cognitive function in elderly women is influenced by a number of health variables, including diabetes, hypertension, and smoking. Other studies have reported association between these factors and progression to dementia in elderly individuals. “In our study we were specifically interested in the associations between cognitive function and DHEAS, social circumstances, and leisure activities,” said Dr. Davis.

The involved researchers predicted that there can be a number of explanations for these findings, including the direct actions of DHEA and DHEAS.

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