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Clopidogrel-related allergic reaction symptoms relieved by steroids and antihistamines

February 3, 2010  |  Posted in  Steroids Blog

Clopidogrel-related allergic reaction symptoms relieved by steroids and antihistaminesA combination therapy involving steroids and antihistamines can be termed as an effective option when it comes to relieving clopidogrel-related allergic reaction symptoms, according to doctors from Thomas Jefferson University Hospital.

Primary Investigator Michael P. Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital and Kimberly L. Campbell, M.D., cardiology fellow and lead author, who presented their findings at the American College of Cardiology’s Annual Scientific Session on March 30 2009, remarked that reaction symptoms after use of clopidogrel, also known by the pharmaceutical name Plavix, may be treated with steroids and antihistamines.

From News-Medical.Net:

“This is a very important study for many cardiac patients but especially those with stents,” said Savage. “Every patient who receives a stent must take Plavix to help prevent stent thrombosis which is clotting of the stent. This obviously poses major problems if the patient suffers an allergic reaction to the medication. To discontinue taking the drug can lead to a heart attack which may be fatal. Those with a drug eluting stent are required to be on the drug for at least one year. Our patients with drug eluting stents actually averaged 17 months on Plavix versus the minimum of one year. That’s a very long time to not be on a medication that may save your life.”

Plavix is one of the most prescribed drugs world-wide. Data from 2007 shows Plavix is the fourth most sold drug in the United States with almost four billion dollars in sales, according to IMS Health, a leading pharmaceutical industry monitoring company. It is estimated that about six percent of those taking the drug showed some signs of an allergic reaction.

John R. Cohn, M.D., chief of Adult Allergy at Thomas Jefferson University and Hospitals and a key contributor to the study said that most of the patients get tolerant to Plavix or desensitized to the drug after being administered with low doses of steroids and antihistamines while continuing the drug.

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