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Androstenedione may improve testosterone levels
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April 24, 2010  |  Posted in  Steroids Blog

Androstenedione may improve testosterone levelsAndrostenedione, a dietary supplement used by some athletes when administered in doses of 300 milligram (mg) can elevate blood testosterone levels in healthy young men as per a study. It was also revealed that an increase in levels of estrogen is also possible with both 100 and 300 mg doses of the supplement. The study, however, did not evaluated if using androstenedione is useful to increase muscle mass or strength or if androstenedione has long-term side effects.

This study was led by researchers from the Massachusetts General Hospital (MGH) and reported in the Feb. 9 issue of the Journal of the American Medical Association.

From Sciencedaily.com:

The MGH-led study was designed only to test the claim that taking oral androstenedione supplements would raise testosterone levels. The research team — led by Benjamin Leder, MD, also of the MGH Endocrine Unit — enrolled 42 healthy men aged 20 to 40 with no previous history of taking androstenedione, steroids or any medication known to affect steroid levels. Participants were divided randomly into three groups: 15 received 100 mg daily doses of androstenedione, 14 received 300 mg doses of androstenedione, and 13 received no androstenedione. During the seven-day study, blood tests taken at frequent intervals after participants took the capsules measured levels of four hormones: androstenedione, testosterone and the estrogens estrone and estradiol.

While the 100 mg doses had no significant effect on testosterone levels, the 300 mg doses increased testosterone levels by an average of 34 percent. In one-third of those taking the 300 mg doses, testosterone levels exceeded the normal range for men. Testosterone levels returned to normal within a day of androstenedione administration. Estrogen levels also increased in both the 100 and 300 mg groups: estrone increased 74 percent at 100 mg and 196 percent at 300 mg, and estradiol increased 42 percent at 100 mg and 128 percent at 300 mg.

Joel Finkelstein, MD, of the MGH Endocrine Unit, the report’s senior author, said that this is the first study to reveal that sufficient doses of Androstenedione do raise serum testosterone.

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