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Activity of genes manipulated by steroid hormones
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April 18, 2010  |  Posted in  Steroids Blog

Activity of genes manipulated by steroid hormonesScientists at the University of Bristol and the National Cancer Institute (NCI), USA have found that intermittent signaling by steroid hormones can affect the manner in which genes are expressed in rodents.

This research is expected to offer major implications for understanding how steroids work and can open novel avenues for new therapies. The research findings were published online and appeared in the September 2009 issue of Nature Cell Biology.

From News-Medical.Net:

The release of hormones by the body’s glands can occur in an episodic, or ultradian, pattern, which consists of repeated periods of release that take place throughout a 24-hour, or circadian, period. Glucocorticoid hormones, which were investigated in this study, are steroid hormones secreted by the adrenal glands that are involved in a large variety of animal and human physiological responses.

Glucocorticoids act through the glucocorticoid receptor, which is expressed in almost every cell in the body and regulates genes controlling development, metabolism, and immune response.

Professor Stafford Lightman, head of the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology at the University of Bristol, remarked that the attained results suggest that hormone release pattern is important for good health along with offering a novel concept for new drug design.

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